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Air Pollution Can Lead To Heart Disease

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A new UCLA study links diesel exhaust with clogged arteries. The finding, published in Genome Biology, describe how the particles from diesel fumes affect the fatty acids in Low Density Lipoprotiens (LDL or "bad" cholesterol) by combining with them and helping to trigger the genes that cause atherosclerosis, or a hardening of the arteries. This interaction significantly increases the chance for a heart attack.

The process was initially observed by combining the pollutants, and fats with cells from human blood vessels.

Dr. Jesus Araujo, UCLA assistant professor of medicine and director of environmental cardiology at the Geffen School of Medicine explained, "We saw that the diesel particles and oxidized fats had worked in tandem to activate the genes that promote cellular inflammation — a major risk factor for atherosclerosis."

The results were later confirmed in live animals using laboratory mice. "Our results emphasize the importance of controlling air pollution as another tool for preventing cardiovascular disease," first author Ke Wei Gong, a UCLA cardiology researcher said.

Source: UCLA

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